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Autoimmune hepatitis

Farhad Sahebjam,John M. Vierling

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 187-219 doi: 10.1007/s11684-015-0386-y

Abstract:

Autoimmune hepatitis is a chronic liver disease putatively caused by loss of tolerance to hepatocyte-specificSince many features also occur in other chronic liver diseases, these scoring systems aid evaluationLiver transplantation represents a life-saving option for patients presenting with acute liver failure

Keywords： autoimmune hepatitis     autoantibodies     diagnosis     immunological diseases     drug-induced liver injury     therapy     immunosuppression     outcomes     hepatocellular carcinoma     liver transplantation    

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Clinical analysis of 275 cases of acute drug-induced liver disease

LI Lei, JIANG Wei, WANG Jiyao

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 58-61 doi: 10.1007/s11684-007-0012-8

Abstract: causative drugs, clinical manifestation and pathological characteristics of the patients with acute drug-inducedliver disease, from January 2000 to December 2005, 275 cases diagnosed as acute drug-induced liver diseasesThe proportion of acute drug-induced liver disease among all of the acute liver injuries was annuallyHepatocellular injury was the predominant type in these cases (132 cases, 48%).The clinicians should pay attention to the prevention, diagnosis and therapy of drug-induced liver disease
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Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-knownliver-restorative herb

Jiabo Wang,Zhijie Ma,Ming Niu,Yun Zhu,Qingsheng Liang,Yanling Zhao,Jingyuan Song,Zhaofang Bai,Yaming Zhang,Ping Zhang,Na Li,Yakun Meng,Qi Li,Lushan Qin,Guangju Teng,Junling Cao,Baosen Li,Shilin Chen,Yonggang Li,Zhengsheng Zou,Honghao Zhou,Xiaohe Xiao

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 457-467 doi: 10.1007/s11684-015-0417-8

Abstract:

Herbal medicines have recently been recognized as the second most common cause of drug-induced liverinjury (DILI) in the United States.In this study, a total of 12 307 inpatients with liver dysfunction and 147 literature-reported cases

Keywords： drug-induced liver injury     pharmacognosy     metabolomics     stilbene     Polygonum multiflorum     Chinese herbal    

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Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic

Nan Qin, Guang Xu, Yan Wang, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Wei Shi, Xiaorong Hou, Chunyu Wang, Ruisheng Li, Yan Liu, Jiabo Wang, Haiping Zhao, Xiaohe Xiao, Zhaofang Bai

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 594-607 doi: 10.1007/s11684-020-0809-2

Abstract: However, liver injury caused by PF and its preparations has been frequently reported in recent years.Our previous studies have demonstrated that PF could cause idiosyncratic drug-induced liver injury (IDILIincreases the levels of aspartate transaminase and alanine aminotransferase in serum and hepatocyte injuryATP- or nigericin-mediated activation of the NLRP3 inflammasome, which may be a dangerous factor for liverinjury.

Keywords： Psoraleae Fructus     bavachin     idiosyncratic drug-induced liver injury     caspase-1     IL-1β     NLRP3 inflammasome    

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Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 104-111 doi: 10.1007/s11684-017-0568-x

Abstract: effect of Rdh13 on liver injury induced by carbon tetrachloride (CCl ).under regular culture, the mice displayed an attenuated response to CCl -induced liver injury.These data suggested that the alleviated liver damage induced by CCl in mice was caused by Cyp2e1This result further implicated Rdh13 as a potential drug target in preventing chemically induced liverinjury.

Keywords： retinol dehydrogenase 13     carbon tetrachloride     acute liver injury     Cyp2e1     Spot14    

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Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels

Shilei ZHENG, Jingru ZHU, Jiao LI, Shuang ZHANG, Yunfei MA

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2,   Pages 197-205 doi: 10.15302/J-FASE-2018245

Abstract: general activity of rats in an open-field test, which was associated with attenuated neuronal damage inducedTaken together, our results demonstrated that leonurine attenuated brain injury during ischemia via antioxidative

Keywords： cerebral ischemia     GABA     neuroprotection     leonurine     SOD    

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Studies of the Guiyuan Fang and Autologous Bone Marrow Stem Cells Transplantation on Hepatic Injury and

Wu Limao,Li Lianda,Liu Hong,Ning Keyong,Li Yikui

Strategic Study of CAE 2004, Volume 6, Issue 7,   Pages 34-42

Abstract: Methods Acute localized liver injury model was induced in rabbits by injecting ethanol locally, and theliver fibrosis models were reproduced by complex factors (high lipid, low protein, alcohol, CClLiver function was assessed by measurement ALT, AST, TP, ALB, and GST.Results In the acute liver injury experiment, the reduction of serum GST levels was remarkable in allparenchyma, along with expression of cytokeratin-18，the liver epithelial specific marker.

Keywords： bone marrow stem cells     autologous transplantation     liver injury     liver fibrosis     guiyuan fang    

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Effect of decoction on CD14 expression in lipopolysaccharide signal transduction pathway of alcohol-inducedliver disease in rats

Rui ZHU MD , Lin SHEN MD , Jianguo LIU MD , Weili ZHANG MM , Ling YANG MD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 363-367 doi: 10.1007/s11684-009-0064-z

Abstract: liver disease in rats.Liver injury was evaluated by biochemical examination.decoction pretreatment significantly protected against acute alcohol-induced liver injury, which wastransduction pathway, which is one of the most important mechanisms of decoction to treat hepatic injuryinduced by alcohol in rats.

Keywords： liver disease     alcohol     Zhihuang decoction     CD14     signal transduction    

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Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

Naci Topaloğlu,Adem Küçük,Şule Yıldırım,Mustafa Tekin,Havva Erdem,Mustafa Deniz

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 368-373 doi: 10.1007/s11684-015-0403-1

Abstract: ) has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion (I/R) injuryHowever, its protective abilities against I/R injury in the liver are unknown.We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats.Blood samples and tissue specimens from the liver were obtained.Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury.

Keywords： ischemia/reperfusion     liver     glucagon-like peptide-2     alanine aminotransferase    

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Accurate Assessment and Tracking the Process of Liver-Specific Injury by the Residual Tissue Activity Article

Qiusha Pan, Peifang Song, Zhenhua Ni, Xingkai Qian, Anqi Wang, Liwei Zou, Yong Liu, Ping Wang, Weidong Zhang, Hong Ma, Ling Yang

Engineering 2022, Volume 19, Issue 12,   Pages 153-165 doi: 10.1016/j.eng.2021.09.014

Abstract:

Accurately assessing and tracking the progression of liver-specific injury remains a major challengeinjury.We found that both QFPDD and UDCA attenuated ANIT-induced liver damage.injury–an application that allows for the differentiation of liver damage and inflammatory liverinjury.

Keywords： Carboxylesterase 1     Dipeptidyl peptidase 4     Liver injury     Validation tracking    

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Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective cohort study

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 111-125 doi: 10.1007/s11684-021-0854-5

Abstract: Although mixed liver impairment has been reported in COVID-19 patients, the association of liver injuryIn addition to previously reported liver impairment markers, such as alanine aminotransferase, aspartate

Keywords： COVID-19     chronic hepatitis B     liver injury     coagulation dysfunction    

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Hypoxia-induced activity loss of a photo-responsive microtubule inhibitor azobenzene combretastatin A4

Yang An, Chao Chen, Jundong Zhu, Pankaj Dwivedi, Yanjun Zhao, Zheng Wang

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 5,   Pages 880-888 doi: 10.1007/s11705-019-1864-6

Abstract: The quantitative drug concentration analysis shows the ratiometric formation of degradation end-products

Keywords： hypoxia     microtubule inhibitor     drug delivery     azo-combretastatin A4     photo-responsive    

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Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 508-511 doi: 10.1007/s11684-015-0418-7

Abstract:

Bile duct injury is a common complication of cholecystectomy.The timing of bile duct injury repair remains controversial.Most patients with bile duct injury present with bile leak and sepsis; thus, early repair is not recommendedendoscopic stenting are the mainstays of treatment of bile leak because they convert acute bile duct injury

Keywords： bile duct injury     cholecystectomy     laparoscopic cholecystectomy    

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Experimental study on the efficacy of Fuganling granula on protecting against immunological hepatic injury

Yanli LIU, Rong LIU, Cheng ZHEN, Quanfang GUO, Liping WU, Zhaoxi DING, Yushun BI, Zhiyu LIU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 91-95 doi: 10.1007/s11684-009-0011-z

Abstract: To study the efficacy of Fuganling granula (FGL, 复肝灵颗粒) in treating mouse immunological hepatic injuryinjury model and then were randomly divided into 5 groups (10 mice/group): 4 groups received treatmentThe liver index and spleen index increased significantly.This experiment established the immunological liver injury model successfully and found that FGL hasa remarkably protective effect on this kind of immunological hepatic injury.

Keywords： Fuganling granula     immunological liver injury     bacille calmette guerin     lipopolysaccharide     mice    

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Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 1-7 doi: 10.1007/s11684-010-0105-7

Abstract:

Partial liver transplantation, including reduced-size liver transplantation, split liver transplantation, and living donor liver transplantation, has been developed with several innovative techniques becauseSplit liver transplantation provides chances to two or even more recipients when only one liver graftBefore surgery, a series of donor evaluations—including anatomical, liver volume, and liver functionAt different recipient conditions, auxiliary liver transplantation and auxiliary partial orthotopic liver

Keywords： partial liver transplantation     reduced-size liver transplantation     split liver transplantation     living donorliver transplantation    

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Title Author Date Type Operation

Autoimmune hepatitis

Farhad Sahebjam,John M. Vierling

Journal Article

Clinical analysis of 275 cases of acute drug-induced liver disease

LI Lei, JIANG Wei, WANG Jiyao

Journal Article

Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-knownliver-restorative herb

Jiabo Wang,Zhijie Ma,Ming Niu,Yun Zhu,Qingsheng Liang,Yanling Zhao,Jingyuan Song,Zhaofang Bai,Yaming Zhang,Ping Zhang,Na Li,Yakun Meng,Qi Li,Lushan Qin,Guangju Teng,Junling Cao,Baosen Li,Shilin Chen,Yonggang Li,Zhengsheng Zou,Honghao Zhou,Xiaohe Xiao

Journal Article

Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic

Nan Qin, Guang Xu, Yan Wang, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Wei Shi, Xiaorong Hou, Chunyu Wang, Ruisheng Li, Yan Liu, Jiabo Wang, Haiping Zhao, Xiaohe Xiao, Zhaofang Bai

Journal Article

Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Journal Article

Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels

Shilei ZHENG, Jingru ZHU, Jiao LI, Shuang ZHANG, Yunfei MA

Journal Article

Studies of the Guiyuan Fang and Autologous Bone Marrow Stem Cells Transplantation on Hepatic Injury and

Wu Limao,Li Lianda,Liu Hong,Ning Keyong,Li Yikui

Journal Article

Effect of decoction on CD14 expression in lipopolysaccharide signal transduction pathway of alcohol-inducedliver disease in rats

Rui ZHU MD , Lin SHEN MD , Jianguo LIU MD , Weili ZHANG MM , Ling YANG MD ,

Journal Article

Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

Naci Topaloğlu,Adem Küçük,Şule Yıldırım,Mustafa Tekin,Havva Erdem,Mustafa Deniz

Journal Article

Accurate Assessment and Tracking the Process of Liver-Specific Injury by the Residual Tissue Activity

Qiusha Pan, Peifang Song, Zhenhua Ni, Xingkai Qian, Anqi Wang, Liwei Zou, Yong Liu, Ping Wang, Weidong Zhang, Hong Ma, Ling Yang

Journal Article

Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective cohort study

Journal Article

Hypoxia-induced activity loss of a photo-responsive microtubule inhibitor azobenzene combretastatin A4

Yang An, Chao Chen, Jundong Zhu, Pankaj Dwivedi, Yanjun Zhao, Zheng Wang

Journal Article

Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Journal Article

Experimental study on the efficacy of Fuganling granula on protecting against immunological hepatic injury

Yanli LIU, Rong LIU, Cheng ZHEN, Quanfang GUO, Liping WU, Zhaoxi DING, Yushun BI, Zhiyu LIU

Journal Article

Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Journal Article